The company’s human pluripotent stem cell (hPSC) technology platform, Human Clinical Trials in a Test Tube™, is based upon a combination of the company’s proprietary and exclusively licensed hPSC technologies.
The platform assesses the toxicity and metabolism (drug-drug interaction) profile of new small molecule drug candidates applicable to a wide range of diseases and conditions. The platform is designed to work at an accelerated and more precise rate than non-clinical in vitro techniques and technologies currently used by biotechnology and pharmaceutical companies.
Among other products, AV-101 is VistaGen’s novel, orally available prodrug candidate for the treatment of neuropathic pain, depression, and potentially other neurological conditions.
In preclinical studies, AV-101 demonstrated positive levels of oral bioavailability, rapid and efficient transport across the blood-brain barrier, and preferential conversion into 7-CKYNA at the site of seizures and potential neural damage in the brain and spinal cord.
The candidate has undergone successful phase 1 development, funded by an $8.8 million grant from the U.S. National Institutes of Health, under an active Investigational New Drug (IND) application with the U.S. FDA.
For more information, visit www.vistagen.com
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