California
biotechnology company International Stem Cell Corp. has announced that the
American Association for the Study of Liver Disease (AASLD) awarded the company
with its Presidential Poster of Distinction at the 64th Annual Liver Meeting in
Washington, D.C.
”Being awarded such
a prestigious honor is a testament to the quality of our scientific team,” said
Ruslan Semechkin, Ph.D., ISCO’s Chief Scientific Officer. “The data presented
at this conference demonstrates the unique nature of our hepatocytes cells
(HLCs) and their potential efficacy in a clinical setting.”
ISCO focuses on the
therapeutic applications of human parthenogenetic stem cells (hpSCs) and the
development and commercialization of cell-based research. The AASLD recognized
a pre-clinical study whose data demonstrated that transplantation of
hpSC-derived HLCs elicits a significant decrease and long-term stabilization of
bilirubin levels in the serum of Gunn rats. Moreover, at four months following
treatment, no adverse safety signals were detected.
Gunn rats are a
well-established animal model of Crigler-Najjar syndrome type 1 (CN1), an
inborn error of bilirubin metabolism. CN1 is a rare inherited liver-based
metabolic disorder in which the host liver lacks one hepatic enzyme, UGT1A1,
which is essential for the conjugation and excretion of the toxin bilirubin.
ISCO’s pre-clinical
study provides evidence that supports the potential safety and efficacy of HLCs
which could constitute a reliable source for large numbers of transplantable
cells. In the long-term, experience with HLC transplantation for CN1 could
potentially be used to develop therapeutic strategies for more common inherited
liver diseases.
Interested parties
can access more information about the company at its website,
www.internationalstemcell.com
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