International Stem
Cell is a biotechnology company leveraging powerful new stem cell technology
called parthenogenesis, which uses unfertilized eggs to advance the field of
regenerative medicine. The company is focusing its use of these cells to treat
diseases of the eye, nervous system, and liver.
Cell therapy for
these indications has been proven clinically. However, therapeutic options are
limited by the availability of safe, immune-matched human cells or tissue. To
address this issue and avoid immune-rejection, International Stem Cell is
pioneering the development of a new class of stem cells called human
parthenogenetic stem cells (hpSCs), which demonstrate the superior
characteristics of other classes of stem cells.
hpSCs are created by
chemical stimulation of unfertilized human eggs to begin division – it’s
important to note that no viable embryo is created or destroyed in this
process. International Stem Cell recently was recognized for its advances
toward the treatment of liver disease based on its hpSC technology.
The company, in
December 2013, was awarded the Presidential Poster of Distinction by the
American Association for the Study of Liver Disease (AASLD) at the 64th Annual
Liver Meeting in Washington, D.C. The data presented at the conference
demonstrated that transplantation of hpSC-derived hepatocytes cells (HLCs) in a
pre-clinical study resulted in a significant decrease and long-term
stabilization of bilirubin levels in the serum of Gunn rats, a well-established
animal model of Crigler-Najjar syndrome type 1 (CN1), a rare and inherited
liver-based metabolic disorder. In the four months following treatment, no adverse
safety signals were detected.
Moving forward,
International Stem Cell continues to advance its technology pipeline to
demonstrate the revolutionary nature of its HLCs and their potential efficacy
for the company’s stated indications.
For more information,
visit www.internationalstemcell.com
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