Seldom a day goes by when some new application of stem cell technology isn’t published, further expanding the breadth of potential for what some are calling a new era in the treatment of disease.
International Stem Cell Corporation is focused on one of the most important aspects of stem cell technology, how to economically source stem cells that won’t be rejected by the body of the person the doctors are trying to save. ISCO’s game-changing solution to the challenge is the development of parthenogenetic stem cells, pluripotent human stem cells created from unfertilized oocytes (eggs).
Parthenogenesis generates stem cells that have a duplicate set of human leukocyte antigen (HLA) genes. This significantly reduces the possibility of the derived cells being rejected by an individual’s immune system. As a result, a single cell line can be suitable for the treatment of millions of individuals, and a relatively small number of such cell lines could be sufficient to provide “immune matched” cells to a significant percentage of the world’s population.
California-based ISCO is now in the process of developing parthenogenetic stem cells (hpSCs) to treat severe diseases of the eye, liver, and brain, for those situations where cell therapy has been shown to be clinically valuable, but which are limited due to the restricted availability of safe immune-matched human cells. The company has created the first parthenogenetic stem cell line that can be a source of therapeutic cells for hundreds of millions of individuals of differing genders, ages, and racial backgrounds, with minimal immune rejection after transplantation. They also produce specialized cells and growth media for therapeutic research worldwide through its subsidiary Lifeline Cell Technology, as well as stem cell-based skin care products through its subsidiary Lifeline Skin Care.
For additional information on ISCO, visit the company’s website at www.InternationalStemCell.com
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