Genetic Immunity, a wholly owned subsidiary of Power of the Dream Ventures, has inked an agreement with DKFZ (German Cancer Research Center, Heidelberg, Germany) to develop a DNA-based vaccine for the treatment of Human Papilloma Virus (HPV) infection that causes cervical and other cancers. The companies are addressing a gap in the market between vaccines such as Cervarix and Gardasil, which have no therapeutic effect on HPV-related diseases, and the need for a product to treat diseases or conditions caused by HPV.
“There is a huge unmet medical need for such cancer vaccine, because vaccines we have developed earlier do not provide protection against cancer when used for treatment of existing conditions caused by HPV. Our goal is to provide protection against cancer for patients after the onset of sexual activity, after they might be exposed to HPV,” Dr. Julianna Lisziewicz, CEO of Genetic Immunity stated in the press release.
The Division of Genome Modifications and Carcinogenesis will commence a preclinical research program to evaluate the therapeutic efficacy of the DKFZ’s HPV-specific plasmid DNA using Genetic Immunity’s nanomedicine formulation and Langerhans cell-targeting administration technologies.
The newly formed collaboration will use Genetic Immunity’s clinically proven technology, as demonstrated in clinical trials of DermaVir as an immunotherapy for the cure of HIV, in its research. The collaboration will test whether HPV-specific memory T cells induced by Genetic Immunity’s nanomedicine products could protect against cancer after infection has already occurred.
“We found that Genetic Immunity technology is unique to target the vaccine DNA into the nucleus of the Langerhans cells. We believe that it will provide a breakthrough in cancer immunotherapy. We pioneered HPV prophylactic vaccines with new innovations and we would like to expand this tradition to therapeutic setting,” said DKFZ’s Dr. Prof. Gissmann, who will initiate the preclinical research program.
For more information visit www.geneticimmunity.com
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