International Stem
Cell, a biotech company focused on the development and commercialization of
stem cell-based research and cosmetic products, recently reported a significant
advancement in human induced pluripotent stem cells (iPS) derivation with novel
protein-based reprogramming method.
iPS cells are made
by genetically reprogramming mature cells, which are usually taken from the
skin, and can be used to create new cells of a different type. Original
reprogramming methods utilize viruses to modify the cells genes and risk the
inclusion of genetic material from the virus into the cells. These viral
methods have proven extremely inefficient and can only produce limited
quantities of cells.
ISCO’s biologists,
however, have developed a fundamentally new method capable of enhancing the
efficiency of the reprogramming process by using specific proteins called
transducible transcription factors (TTF), while avoiding the use virus-based
methods and the inherent risks associated with such methods.
The company’s new
method demonstrates that its TTF-iPS technology has the ability to produce
stable stem cells and is at least 10 times more efficient that older methods.
In addition, the TTFs are naturally eliminated when no longer required, a
characteristic that further improves safety.
“This new method
offers a much needed safer and more efficient alternative to older techniques
and represents a major step forward in being able to use iPS clinically,” Dr.
Ruslan Semechkin, chief scientific officer for ISCO, stated in the news
release. “We are currently working toward shortening the cell reprogramming
step from around six weeks to as little as one week.”
For more
information, visit www.internationalstemcell.com
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