Advaxis, a biotechnology company developing the next generation of immunotherapies for cancer and infectious diseases, is developing a novel platform technology using live, attenuated bacteria that are bio-engineered to secrete an antigen/adjuvant fusion protein that redirects the powerful immune response all human beings have to the bacteria to the cancer itself.
The company’s approach has been determined to outsmart tumor protection reactions that foil other treatments, while also generating a long-term immune system “memory” that is able to hunt down cancer cells throughout the body beyond the initially targeted antigens. And, being an immunotherapy, it does it all without the poisons and associated side effects of traditional chemotherapy treatments.
Advaxis immunotherapies are designed to stimulate many complementary immune mechanisms of action, including:
• Strong innate immune effects
• Strong adaptive immune effects
• Reduction of both Tregs and MDSCs in tumors but not in other tissues or systemically
• Memory generation that is not impaired by antibiotics administered immediately after dosing
• Chemotaxis and extravasation of activated immune cells
• Upregulation of tumor chemokines and chemokines receptors
• Epitope and antigen spreading
• A predominantly cellular immune response with little antibody formation
Over 15 distinct constructs are in various stages of development, either developed directly by Advaxis or through strategic collaborations with recognized centers of excellence, such as the National Cancer Institute. The company’s first construct, ADXS-HPV, is being evaluated in 4 Phase 2 clinical trials for HPV associated diseases (CIN 2/3, cervical cancer, and head & neck cancer). In addition, Advaxis has developed immunotherapies for prostate cancer and HER2 expressing cancers (such as breast, gastric, bladder, brain, pancreatic, ovarian cancer, and canine osteosarcoma).
For additional information, visit www.Advaxis.com
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